{"id":509,"date":"2017-07-26T16:15:03","date_gmt":"2017-07-26T14:15:03","guid":{"rendered":"http:\/\/www.leventkabasakal.com\/?p=509"},"modified":"2017-08-07T15:17:15","modified_gmt":"2017-08-07T13:17:15","slug":"prostat-kanserinde-yeni-atom-tedavisi-radyum-223","status":"publish","type":"post","link":"https:\/\/www.leventkabasakal.com\/en\/recent\/prostat-kanserinde-yeni-atom-tedavisi-radyum-223\/","title":{"rendered":"Prostat Kanseri Yeni Atom Tedavisi: Radyum-223"},"content":{"rendered":"

Prostat kanseri tedavisi cerrahi tedavi, \u0131\u015f\u0131n tedavisi ve hormon tedavisi gibi \u00e7ok \u00e7e\u015fitli tedavi y\u00f6ntemleri hastal\u0131\u011f\u0131n durumu ve ya\u015f\u0131na g\u00f6re kullan\u0131labilir. Hastal\u0131k metastaz (s\u0131\u00e7rama) olu\u015fturursa bu durumda kullan\u0131labilecek kemoterapi ila\u00e7lar\u0131 vard\u0131r. Kemoterapi ila\u00e7lar\u0131n\u0131n yan\u0131nda kemik metastazlar\u0131 i\u00e7in e\u011fer \u00e7ok say\u0131da de\u011fil ise \u0131\u015f\u0131n tedavisi de uygulanabilir.<\/span><\/span><\/p>\n

E\u011fer kemik metastazlar\u0131n\u0131n say\u0131s\u0131 \u00e7oksa bu durumda \u0131\u015f\u0131n tedavisi uygulanamaz. 2013 y\u0131l\u0131nda Radyum-223 (Ra-223) denilen atom tedavisi yeni bir ila\u00e7 olarak geli\u015ftirilmi\u015f ve kullan\u0131ma girmi\u015ftir. \u00dclkemizde halen ruhsatland\u0131rma a\u015famas\u0131nda bulunmaktad\u0131r ve k\u0131sa s\u00fcre i\u00e7erisinde kullan\u0131ma girmesi beklenmektedir.<\/span><\/span><\/p>\n

Radyum-223, bir\u00a0<\/span><\/span>alkali toprak metali<\/span><\/span>\u00a0olan\u00a0<\/span><\/span>radyumun radyoaktif bir izotopudur.<\/span>\u00a0Radyum kimyasal a\u00e7\u0131dan kalsiyuma benzerlik g\u00f6sterir ve kemikte hastal\u0131kl\u0131 b\u00f6lgeye girerek yerle\u015fir.<\/span><\/span>\u00a0<\/span><\/span><\/span>Ra-223 kemik metastazlar\u0131ndaki kanserli h\u00fccreler \u00fczerine etki g\u00f6steren,\u00a0<\/span><\/span>bir \u03b1 partik\u00fcl\u00fc denilen \u0131\u015f\u0131n yayan atom tedavisi y\u00f6ntemidir.\u00a0<\/span>\u03b1-partik\u00fcllerin doku i\u00e7erisinde gidebildi\u011fi mesafe \u00e7ok k\u0131sa oldu\u011fundan (2-10 h\u00fccre), Ra-223 uygulamas\u0131 sonras\u0131nda kemik ili\u011fi gibi di\u011fer normal organlara \u00f6nemli bir zarar vermez.<\/span><\/span><\/span><\/p>\n

T\u00fcm bu \u00f6zellikler neticesinde de, sadece kemik metastaz\u0131 olan ve i\u00e7 organ metastaz\u0131 olmayan prostat kanseri hastalar\u0131nda yap\u0131lan Faz III \u00e7al\u0131\u015fmada (ALSYMPCA), Ra-223 ya\u015fam s\u00fcresinde art\u0131\u015f ve a\u011fr\u0131n\u0131n giderilmesi avantaj\u0131n\u0131 sa\u011flamaktad\u0131r. Hastalar\u0131n ya\u015fam kaliteleri \u00f6nemli oranda artmaktad\u0131r.<\/span><\/span><\/p>\n

Ra-223, 10 ml\u2019lik vial i\u00e7inde 6 ml\u00a0<\/span><\/span>radyoaktif madde sol\u00fcsyonu<\/b><\/u><\/span><\/span>\u00a0i\u00e7eren \u015fi\u015feler halinde bulunmaktad\u0131r ve hastalara 4’er hafta arayla 6 enjeksiyon olarak verilmektedir. Ra-223 genel olarak 1 dakikaya kadar s\u00fcren yava\u015f intraven\u00f6z enjeksiyon ile uygulanmal\u0131d\u0131r. Bu tedavi sonras\u0131nda genellikle \u00f6nemli bir radyasyon d\u0131\u015far\u0131ya yay\u0131lmaz ve hasta g\u00fcnl\u00fck ya\u015fant\u0131s\u0131n\u0131 s\u00fcrd\u00fcr\u00fcr. Hastanede yatmas\u0131na gerek yoktur. Hastalarda sa\u00e7 d\u00f6k\u00fclmesi, bulant\u0131, kusma gibi yan etkiler g\u00f6r\u00fclmez.<\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Prostat kanseri, erkeklerde en s\u0131k g\u00f6r\u00fclen ikinci kanser t\u00fcr\u00fcd\u00fcr. Kansere ba\u011fl\u0131 \u00f6l\u00fcmlerde de \u00fcst s\u0131ralardad\u0131r. Hastal\u0131\u011f\u0131n seyri ba\u015fta kemik olmak \u00fczere \u00e7e\u015fitli b\u00f6lgelere s\u0131\u00e7ramas\u0131na ba\u011fl\u0131d\u0131r. Prostat kanserinde, en s\u0131k s\u0131\u00e7rama yeri kemiktir ve a\u011fr\u0131ya sebep olarak hastan\u0131n ya\u015fam kalitesinin bozulmas\u0131na neden olur. Ayr\u0131ca kemiklere s\u0131\u00e7ramas\u0131 hastan\u0131n hayat\u0131n\u0131 da tehdit eder.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[4],"tags":[],"class_list":["post-509","post","type-post","status-publish","format-standard","hentry","category-guncel"],"_links":{"self":[{"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/posts\/509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/comments?post=509"}],"version-history":[{"count":0,"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/posts\/509\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/media?parent=509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/categories?post=509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.leventkabasakal.com\/en\/wp-json\/wp\/v2\/tags?post=509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}